Market Research Report

Global Hepatocellular Carcinoma (HCC) Market Research Report: (2022-2027)

By Diagnosis (Blood Tests (AFP (Alfa-Fetoprotein), LFT (Liver Function Test)), Hepatic Angiography, Liver Biopsy, Laparoscopy, Others (MRI, CT scan, etc.)), By Treatment (Surgery (...Hepatectomy, Liver Transplant), Radiation Therapy, Chemotherapy (Cisplatin, Gemcitabine (Gemzar), Oxaliplatin (Eloxatin), Doxorubicin (pegylated liposomal doxorubicin), 5-fluorouracil (5-FU)), Targeted Drug Therapy (Kinase Inhibitors (Sorafenib, Lenvatinib, Regorafenib (Stivarga), Cabozantinib (Cabometyx)), Monoclonal Antibodies (Bevacizumab (Avastin), Ramucirumab (Cyramza))), Immunotherapy (Atezolizumab (Tecentriq), Pembrolizumab (Keytruda), Nivolumab (Opdivo), Ipilimumab (Yervoy))), By End-User (Hospitals, Cancer Centers, Others (Ambulatory Surgery Centers, etc.)), By Region (North America, South America, Europe, Middle East & Africa, Asia-Pacific), By Country (The US, Canada, Mexico, Brazil, The UK, Germany, France, Italy, Spain, South Africa, GCC, China, Japan, India, Australia, South East Asia) Read more

  • Healthcare
  • Jun 2022
  • 198
  • HC22082

Market Definition

Hepatocellular Carcinoma (HCC) is a liver malignancy that emerges in liver cells and is the sixth most common cancer worldwide. It is the third most cause of cancer-related deaths globally, with prominent risk factors, including excessive alcohol consumption, HBV (Hepatitis B Virus) & HCV (Hepatitis C Virus) infections, and other lifestyle disorders.

Market Insights

The Global Hepatocellular Carcinoma (HCC) Market is projected to grow at a CAGR of around 10.20% during the forecast period, i.e., 2022-27. The growth of the market is driven primarily by the increasing instances of liver cancer & rising mortality rates owing to severe lifestyle changes and increasing obesity on account of poor eating habits, coupled with significant investments in research activities associated with the development of advanced therapeutics for HCC.

Report Coverage Details
Study Period Historical Data: 2017-20
Base Year: 2021
Forecast Period: 2022-27
CAGR 10.20%
Regions Covered North America: The US, Canada, Mexico
Europe: Germany, The UK, Germany, France, Italy, Spain, Rest of Europe
Asia-Pacific: China, Japan, India, Australia, South East Asia, Rest of Asia-Pacific
South America: Brazil, Rest of Latin America
Middle East & Africa: South Africa, GCC, Rest of Middle East & Africa
Key Companies Profiled

Amgen Inc., AstraZeneca plc, Bayer AG, BeiGene, Bristol Myers Squibb, Eisai Co., Ltd., Merck & Co., Inc., Novartis International AG, Pfizer Inc.

Unit Denominations USD Million/Billion

 

Moreover, the rapidly surging clinical trials for HCC drugs & medications by the leading biotech & pharma companies are further creating lucrative prospects for the global market through 2027. FDA, PMDA, & EMA, among other regulatory agencies worldwide, are offering significant incentives to biopharma companies for developing orphan drugs for rare diseases while also providing fast drug approvals. For instance:

  • In April 2022, FDA granted Orphan Drug Designation (ODD) to TTI-101, an orally delivered, small molecule, STAT3 inhibitor developed by Tvardi Therapeutics, Inc., for HCC treatment.
  • In February, the US-based agency authorized ODD to two autologous & gene-edited T-cell immunotherapies (ET140203 & ECT204, developed by Eureka Therapeutics) for the treatment of patients with advanced HCC.

With the FDA approval of Avastin (bevacizumab) and Tecentriq (atezolizumab) as the first-line HCC treatment, healthcare R&D has been focusing extensively on developing more effective and affordable combination therapies.

Combinations of PD- 1 or PDL- 1 with multikinase inhibitors, anti-VEGF drugs, or CTLA- 4 inhibitors are already well represented in late-stage HCC. As a result, the rising cases of liver cancer worldwide are creating numerous opportunities for these medications, which, in turn, would expand the global market in the years to come.

However, adverse effects like skin & gastrointestinal disorders, fatigue, hair loss, etc., in many patients suffering from HCC due to high drug dosage, coupled with the unavailability of HCC diagnoses & treatments in rural areas, are a few aspects projected to hinder the growth of the Global Hepatocellular Carcinoma (HCC) Market through 2027.


Global Hepatocellular Carcinoma (HCC) Market Research Report: (2022-2027)

Market Segmentation

Based on Treatment:

  • Chemotherapy
    • Cisplatin
    • Gemcitabine (Gemzar)
    • Oxaliplatin (Eloxatin)
    • Doxorubicin (pegylated liposomal doxorubicin)
    • 5-fluorouracil (5-FU)
  • Immunotherapy
    • Atezolizumab (Tecentriq)
    • Pembrolizumab (Keytruda)
    • Nivolumab (Opdivo)
    • Ipilimumab (Yervoy)
  • Surgery
    • Hepatectomy
    • Liver Transplant
  • Radiation Therapy
  • Targeted Therapy
    • Kinase Inhibitors
      • Sorafenib
      • Lenvatinib
      • Regorafenib (Stivarga)
      • Cabozantinib (Cabometyx)
    • Monoclonal Antibodies
      • Bevacizumab (Avastin)
      • Ramucirumab (Cyramza)

Of all treatments, targeted therapy drugs like Sorafenib & Lenvatinib (kinase inhibitors) led the Global Hepatocellular Carcinoma (HCC) Market in previous years. For many years, they have been the SOC (standard of care) treatment of patients with advanced HCC. Sorafenib is oral bi-aryl urea that inhibits multiple cell surface & downstream kinases involved in tumor progression. Phase 3 randomized placebo-controlled trials conducted across regions like the Americas, Asia, & Europe made Sorafenib a preferred systematic therapy for advanced HCC. It was due to improved OS (overall success) rates in patients, coupled with mild to moderate severity of toxicities, such as hand-foot skin reactions, fatigue, & diarrhea.

However, in May 2020, FDA approved the combination of Avastin (bevacizumab) & Tecentriq (atezolizumab) as the first-line treatment for patients suffering from metastatic or unresectable hepatocellular carcinoma. The combination therapy, i.e., only for those with no history of any systemic therapy, showed enhanced efficacy & safety compared to kinase inhibitors and is projected to dominate the Global Hepatocellular Carcinoma (HCC) Market throughout 2027.

Based on Diagnosis:

  • Blood Tests
    • AFP (Alfa-Fetoprotein)
    • LFT (Liver Function Test)
  • Hepatic Angiography
  • Liver Biopsy
  • Laparoscopy
  • Others (MRI, CT scan, etc.)

Of all HCC diagnoses, blood tests are the most commonly used laboratory tests owing to their accuracy & cost-efficiency. AFP blood tests help identify the treatment, and LFTs, with relatively higher demand than AFP, provide precise information on the liver condition. These tests are considered ideal for screening patients with a significant risk of hepatocellular carcinoma, specifying the disease stage, determining appropriate treatment options, & assessing if there's any response from the disease to the prescribed treatment.

However, rigorous research is being conducted extensively on developing more accurate, efficient, & cost-effective HCC diagnoses. The study areas include the use of receptors & growth factors, enzymes & isoenzymes biomarkers, & molecular markers for the liver cancer diagnoses, portraying promising potential in the nearer future.

On the other hand, after lab tests, imaging diagnoses like CT scans, MRI, hepatic angiography, laparoscopy, etc., help confirm the tumor presence in patients. These tests aid healthcare professionals in the better evaluation of results generated by lab & genetic tests and know the nature & extent of the tumor. One of the most prominent demand barriers for imaging tests is the radiation exposure that may result in severe effects on account of fluorescent & radioactive materials used for image formation.

Nevertheless, with rapid technological advancements, imaging tests are becoming more accurate, safe, efficient, & cost-effective, which projects their significantly surging demand for hepatocellular carcinoma diagnosis over the coming years.

Regional Landscape

Geographically, the Global Hepatocellular Carcinoma (HCC) Market expands across:

  • North America
  • South America
  • Europe
  • Middle East & Africa
  • Asia-Pacific

Of all regions globally, North America holds a significant share in the Hepatocellular Carcinoma (HCC) Market. It attributes to the well-established healthcare facilities, excellent policies for healthcare insurance reimbursement, the extensive presence of leading biopharma companies & various strategic initiatives by them, the rising geriatric population, and the early adoption of advanced diagnosis & treatments for cancer, including HCC, across the region.

The US holds the major share in the regional market for hepatocellular carcinoma due to rapid technological advancements in drug development, massive R&D investments in developing more effective treatments for HCC, and the easily & extensively available cancer therapeutic drugs in the country.

On the other hand, Asia-Pacific is projected to record the highest market growth rate through 2027. It owes to the mounting prevalence of HBV & HCV, aging populations, and a significant rise in alcohol consumption. Moreover, governments of regional countries are taking various initiatives toward making people aware of the importance & availability of early detection of these diseases. In addition, there is a burgeoning adoption of more effective & accurate diagnostic procedures for HCC, especially in countries like India & China, i.e., another crucial aspect driving the regional market.

Besides, the reducing prices of diagnostics solutions and notable developments in the healthcare infrastructure across the region shall further propel the overall market growth over the coming years. Across Asia-Pacific, China is observing a significantly growing medical tourism sector, coupled with massive funding by the leading biotech & pharma companies in the R&D of cost-effective treatments for HCC.

Key Market Driver: Substantial R&D Investments by Leading Pharma & Biotech Companies Worldwide

The key companies in the biotechnology & pharmaceutical ecosystem are massively investing in R&D activities associated with discovering & implementing more efficient & accurate diagnoses & treatments for hepatocellular cancer. As a result of the rising patient pool of HCC, there's a burgeoning demand for oncology drugs, coupled with increasing strategic collaborations to expand the product portfolio, which, in turn, would drive the Global Hepatocellular Carcinoma (HCC) Market during 2022-27.

Key Questions Answered in the Market Research Report:

  1. What are the overall statistics or estimates (Overview, Size- By Value, Forecast Numbers, Segmentation, Shares) of the Global Hepatocellular Carcinoma (HCC) Market?
  2. What are the region-wise industry size, growth drivers, and challenges?
  3. What are the key innovations, opportunities, current & future trends, and regulations in the Global Hepatocellular Carcinoma (HCC) Market?
  4. Who are the key competitors, their key strengths & weaknesses, and how do they perform in the Global Hepatocellular Carcinoma (HCC) Market based on the competitive benchmarking matrix?
  5. What are the key results derived from surveys conducted during the Global Hepatocellular Carcinoma (HCC) Market study?

Frequently Asked Questions

   A. The Global Hepatocellular Carcinoma (HCC) Market is projected to grow at a CAGR of around 10.20% during 2022-27.

   A. Growing investments by the leading biopharma companies in developing more advanced & effective HCC diagnosis & treatment entwined with increasing healthcare expenditure by governments of different countries worldwide are the prominent factors projected to drive the Global Hepatocellular Carcinoma (HCC) Market through 2027. On the other hand, severe side effects in HCC patients due to high dosage of drugs might hamper the market growth in the coming years.

   A. Targeted therapy would generate remunerative opportunities for the leading players operating in the Global Hepatocellular Carcinoma (HCC) Market over the forecast years.

  1. Introduction
    1. Research Process
    2. Assumption
    3. Market Segmentation
    4. Market Definition
  2. Executive Summary
  3. Global Hepatocellular Carcinoma (HCC) Market Trends & Insights
  4. Global Hepatocellular Carcinoma (HCC) Market Regulation & Policy, By Country
  5. Global Hepatocellular Carcinoma (HCC) Market Dynamics
    1. Growth Drivers
    2. Challenges
    3. Impact Analysis
  6. Global Hepatocellular Carcinoma (HCC) Market Hotspot and Opportunities
  7. Global Hepatocellular Carcinoma (HCC) Market Outlook, 2017- 2027
    1. Market Size and Analysis
      1. By Revenues in USD Million
    2. Market Share and Analysis
      1. By Diagnosis
        1. Blood Tests
          1. AFP (Alfa-Fetoprotein)
          2. LFT (Liver Function Test)
        2. Hepatic Angiography
        3. Liver Biopsy
        4. Laparoscopy
        5. Others (MRI, CT scan, etc.)
      2. By Treatment
        1. Chemotherapy
          1. Cisplatin
          2. Gemcitabine (Gemzar)
          3. Oxaliplatin (Eloxatin)
          4. Doxorubicin (pegylated liposomal doxorubicin)
          5. 5-fluorouracil (5-FU)
        2. Immunotherapy
          1. Atezolizumab (Tecentriq)
          2. Pembrolizumab (Keytruda)
          3. Nivolumab (Opdivo)
          4. Ipilimumab (Yervoy)
        3. Surgery
          1. Hepatectomy
          2. Liver Transplant
        4. Radiation Therapy
        5. Targeted Therapy
          1. Kinase Inhibitors
            1. Sorafenib
            2. Lenvatinib
            3. Regorafenib (Stivarga)
            4. Cabozantinib (Cabometyx)
          2. Monoclonal Antibodies
            1. Bevacizumab (Avastin)
            2. Ramucirumab (Cyramza)
      3. By End-User
        1. Hospitals
        2. Cancer Centers
        3. Others (Ambulatory Surgery Centers, etc.)
      4. By Region
        1. North America
        2. South America
        3. Europe
        4. Middle East & Africa
        5. Asia-Pacific
      5. By Company
        1. Competition Characteristics
        2. Revenue Shares
        3. Competitor Placement in MarkNtel Advisor’s Quadrant
  8. North America Hepatocellular Carcinoma (HCC) Market Outlook, 2017- 2027
    1. Market Size and Analysis
      1. By Revenues in USD Million
    2. Market Share and Analysis
      1. By Diagnosis
      2. By Treatment
      3. By End-User
      4. By Country
        1. The US
        2. Canada
        3. Mexico
  9. South America Hepatocellular Carcinoma (HCC) Market Outlook, 2017- 2027
    1. Market Size and Analysis
      1. By Revenues in USD Million
    2. Market Share and Analysis
      1. By Diagnosis
      2. By Treatment
      3. By End-User
      4. By Country
        1. Brazil
        2. Rest of Latin America
  10. Europe Hepatocellular Carcinoma (HCC) Market Outlook, 2017- 2027
    1. Market Size and Analysis
      1. By Revenues in USD Million
    2. Market Share and Analysis
      1. By Diagnosis
      2. By Treatment
      3. By End-User
      4. By Country
        1. The UK
        2. Germany
        3. France
        4. Italy
        5. Spain
        6. Rest of Europe
  11. Middle East & Africa Hepatocellular Carcinoma (HCC) Market Outlook, 2017- 2027
    1. Market Size and Analysis
      1. By Revenues in USD Million
    2. Market Share and Analysis
      1. By Diagnosis
      2. By Treatment
      3. By End-User
      4. By Country
        1. South Africa
        2. GCC
        3. Rest of Middle East & Africa
  12. Asia-Pacific Hepatocellular Carcinoma (HCC) Market Outlook, 2017- 2027
    1. Market Size and Analysis
      1. By Revenues in USD Million
    2. Market Share and Analysis
      1. By Diagnosis
      2. By Treatment
      3. By End-User
      4. By Country
        1. China
        2. Japan
        3. India
        4. Australia
        5. South East Asia
        6. Rest of Asia Pacific
  13. Global Hepatocellular Carcinoma (HCC) Market Key Strategic Imperatives for Success and Growth
  14. Competitive Outlook
    1. Competition Matrix
      1. By Application Portfolio
      2. Brand Specialization
      3. Target Markets
      4. Target by Applications
      5. Research & Development
      6. Strategic Alliances
      7. Strategic Initiatives
    2. Company Profiles (Business Description, By Application Segments, Business Segments, Financials, Strategic Alliances/ Partnerships, Future Plans)
      1. Amgen Inc.
      2. AstraZeneca plc
      3. Bayer AG
      4. BeiGene
      5. Bristol Myers Squibb
      6. Eisai Co., Ltd.
      7. Merck & Co., Inc.
      8. Novartis International AG
      9. Pfizer Inc.
  15. Disclaimer


 Hepatocellular Carcinoma (HCC) Market Segmentation